毒品与药物滥用分析
FORENSIC TOXICOLOGY
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样品类型（基质） |
分析物 | MicroSep® 产品 | 参考文献 |
| 尿样 | 治疗药物⁄滥用药物 | 对于不同应用，MicroSep® 为您提供装填不同树脂的 DPX tips。如WAX⁄RP(mixed mode)、SCX | Journal of Analytical Toxicology |
| 尿样 | 大麻⁄四氢大麻酚(THC) | MicroSep® DPXtips with WAX | Journal of Analytical and Bioanalytical Chemistry |
| 尿样 | 环苯扎林，阿米替林 | MicroSep® DPXtips with RP | Journal of Analytical Toxicology |
| 尿液,血液,肝组织,脑组织和胃内容物 | 苯二氮卓类 | MicroSep® DPXtips with WAX | Journal of Analytical Toxicology |
| 唾液 | 治疗药物⁄滥用药物 | MicroSep® DPXtips with WAX⁄RP(mixed mode) | |
| 血液⁄血清 | 大麻 ⁄四氢大麻酚(THC) | MicroSep® DPXtips with WAX | Journal of Analytical Toxicology ⁄ Journal of Chromatography AJournal of Chromatography |
| 血液⁄血清 | 鸦片类药物 | MicroSep® ToT Filtration | SOFT 2019 Poster Presentation |
| 大麻植物与工业制药原料 | 大麻 ⁄四氢大麻酚(THC) | MicroSep® DPXtips with RP |
应用文献
● Rapid Room Temperature Hydrolysis of Glucuronidated Drugs of Abuse using IMCSzyme® RT
● Hydrolysis of sulfated steroids, toxic endobiotics and xenobiotics using purified sulfatase for quantitation of sulfated and unconjugated compounds
● Conversion of drug metabolites due to contaminants in commercialβ-glucuronidase products
● degradation and Conversion of Opioids and Opiates during acid hydrolysis
● The Importance of pH in β-Glucuronidase Hydrolysis Efficiency
● rapid hydrolysis of Glucuronidated opiates and opioids in urine using Imcszyme®
● 使用 IMCSzyme® 在 15 分钟内完成对浓度为 30,000 ng⁄mL 的 6-葡萄糖醛酸代可待因的高效水解
● 《使用 IMCSzyme® 对尿样中海洛因代谢产物 6-单乙酰吗啡的精准定量分析》摘要
● Improving Benzodiazepine Immunoassay Sensitivity by Rapid Glucuronide Hydrolysis Technology
● 《应用 LDTD-MS⁄MS 在 9 秒内完成尿样中抗抑郁药物超快速定量分析》摘要
● 《利用 IMCSzyme® 优化血样中的鸦片类化合物水解及萃取条件》摘要
● 《使用新型重组 β-葡萄糖醛酸酶对丁丙诺啡的水解效率分析》摘要
● 《利用新型重组 β-葡萄糖醛酸酶对尿样中的纳洛酮进行水解及 LC-MS/MS 分析》摘要
● 《利用新型重组 β-葡萄糖醛酸酶进行尿样中的鸦片类药品的水解及定量分析》摘要
● A summary of “Screening and Quantification of Pain and Antidepressant Drugs in Human Urine by Liquid Chromatography-High Resolution Mass Spectrometry”
● A summary of “Rapid Enzyme Hydrolysis Using a Novel Recombinant β-Glucuronidase in Benzodiazepine Urine Analysis”
● A summary of “Meconium Targeted Drug Screening in 9 seconds per Sample Using Laser Diode Thermal Desorption Mass Spectrometry (LDTD-MS⁄MS)”
● A summary of “LC-MS/MS Method for the Determination of Tricyclic and Tetracyclic Antidepressants in Human Urine”
● A summary of “Hydrolyze Your Way to Compliance – A Call for Pain Management Certified Reference Materials”
● A summary of “Isomer interferences observed during the development of a 47-analyte HRAM LC-MS⁄MS method for urine drug testing”
● A summary of “Fast Simple, and Accurate Method for Urine Drugs of Abuse Screening and Quantitation Using Liquid Chromatography with Time of Flight (TOF) Mass”
● A summary of “Comparison of Novelβ-Glucuronidases for Process Improvement in Urine Toxicology Workflows”
● A summary of “Uromics: Metabolomics in Urine for Seroquel®, Latuda®, and Haldol®”
期刊文献
Rosano TG, Ohouo PY, Wood M.
Journal of Analytical Toxicology; 43(5):353-63. doi: 10.1093/jat/bky106
● Stability and Hydrolysis of Desomorphine-Glucuronide.?Journal of Analytical Toxicology.
Winborn J, Kerrigan S.
Journal of Analytical Toxicology; doi: 10.1093/jat/bkz021.
● Characterization of an Amphetamine Interference from Gabapentin in an LC–HRMS Method.
Muñoz-Muñoz AC, Pekol T, Schubring D, Hyland R, Johnson C, Andrade L.
Journal of Analytical Toxicology; doi: doi: 10.1093/jat/bkz046.
● Identification of Novel Opioid Interferences using High-Resolution Mass Spectrometry.
Muñoz-Muñoz AC, Pekol T, Schubring D, Johnson C, Andrade L.ccess
Journal of Analytical Toxicology; 42(1):6-16. doi: 10.1093/jat/bkx065.
● Impact of β-Glucuronidase Mediated Hydrolysis on Haldol® Urinalysis.
Cummings OT, Strickland EC, Enders JR, McIntire GL.
Journal of Analytical Toxicology; 42(4):214-219. doi: 10.1093/jat/bkx103.
● Zolpidem and Zolpidem Carboxylic Acid Results from Medication Monitoring.
Feng S, Cummings OT, McIntire G.
Journal of Analytical Toxicology; 42(7):491-5. doi: 10.1093/jat/bky033.
● Systematic Evaluation and Validation of Benzodiazepines Confirmation Assay Using LC-MS-MS.
Kang MG, Lin HR.
Journal of Analytical Toxicology; 43(2):96-103. doi: 10.1093/jat/bky071.
● Development and Validation of a Novel All-Inclusive LC–MS-MS Designer Drug Method.
Strickland EC, Cummings OT, McIntire GL, Mellinger AL.
Journal of Analytical Toxicology; 43(3):161-9. doi: 10.1093/jat/bky087.
Sitasuwan P, Melendez C, Marinova M, Spruill M, Lee LA.
Journal of Analytical Toxicology; 43(3):221-227. doi: 10.1093/jat/bky082
Dwivedi P, Zhou X, Powell TG, Calafat AM, Ye X.
Chemosphere; 199:256-62. doi: 10.1016/j.chemosphere.2018.01.177.
● Opiate & Benzodiazepine Confirmations: To Hydrolyze or Not to Hydrolyze is the Question.
Johnson-Davis KL.
Journal of Applied Laboratory Medicine; 2(4):564. doi: 10.1373/jalm.2016.022947. Review Article.
● Internal Hydrolysis Indicator for Sample Specific Monitoring of β-Glucuronidase Activity.
Taylor LL, Flint NA, Ma V, Hill BM, Clark CJ, Strathmann FG.
Journal of Analytical Toxicology;41(5):407-411. doi: 10.1093/jat/bkx027.
Rosano TG, Ohouo PY, Wood M.
Journal of Analytical Toxicology;41(6):536-46. doi: 10.1093/jat/bkx035.
Yang HS, Wu AH, Lynch KL.
Journal of Analytical Toxicology;40(5):323-329. doi: 10.1093/jat/bkw026.
Sitasuwan P, Melendez C, Marinova M, Mastrianni K, Darragh A, Ryan E, Lee LA.
Journal of Analytical Toxicology;40(8):601-607. doi: 10.1093/jat/bkw085.
Rosano TG, Ohouo PY, LeQue JJ, Freeto SM, Wood M.
Journal of Analytical Toxicology;40(8):628-38. doi: 10.1093/jat/bkw050.
● Variations in enzymatic hydrolysis efficiencies for amitriptyline and cyclobenzaprine in urine.
Mastrianni KR, Lee LA, Brewer WE, Dongari N, Barna M, Morgan SL.
Journal of Analytical Toxicology;40:732-737. doi: 10.1093/jat/bkw062.
● Rapid Enzymatic Hydrolysis Using a Novel Recombinant β-Glucuronidase in Benzodiazepine Urinalysis.
Morris AA, Chester SA, Strickland EC, McIntire GL.
Journal of Analytical Toxicology;38(8):610-614. doi: 10.1093/jat/bku083.
● Comprehensive Analysis of Drugs of Abuse in Urine Using Disposable Pipette Extraction
Sparkle T. Ellison,William E. Brewer,Stephen L. Morgan
doi: 10.1093/jat/33.7.356.
Maria Andersson, Karl B. Scheidweiler, Cristina Sempio, Allan J. Barnes & Marilyn A. Huestis
doi: 10.1007/s00216-016-9765-8.
Karl B. Scheidweiler，Matthew N.Newmeyer，Allan J.Barnes，Marilyn A.Huestis
doi: 10.1016/j.chroma.2016.05.024.
Dani C. Mata, John F. Davis, Ariana K. Figueroa, Mary June Stanford
doi: 10.1093/jat/bkv111.
