PO0016 Rapid Hydrolysis of Glucuronidated Opiates and Opioids in Urine Using IMCSzyme®
来源:IMCS
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作者:Cathleen Melendez,
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发布时间: 1714天前
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1958 次浏览
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• Recreational opiate and opioid use has become an increasing cause of deaths due to drug over dose.
• Codeine-6-β-D-glucuronide is one of the more challenging drug metabolites for β-glucuronidases to hydrolyze.
• >80% hydrolysis of 30,000 ng/mL codeine-6-β-D-glucuronide was achieved in 15 minutes using only 3000 units of IMCSzyme (60µL per 30µL urine).
• Codeine-6-β-D-glucuronide is one of the more challenging drug metabolites for β-glucuronidases to hydrolyze.
• >80% hydrolysis of 30,000 ng/mL codeine-6-β-D-glucuronide was achieved in 15 minutes using only 3000 units of IMCSzyme (60µL per 30µL urine).
Opiates and opioids are commonly prescribed for pain management and can easily become addictive. Teirrecreational use has significant lyincreased over the past 15 years,and therate of deaths due to opioid over dose has tripled since the year 2000.
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