Pesticides continue to contribute significantly to controlling and destroying various types of agricultural pests and thereby improving food production throughout the world. However, uncontrolled pesticide use has led to the deaths of animals and humans (1). The publication of Rachel Carson’s book Silent Spring (2) is often acknowledged for increasing awareness of the potential health hazards posed by pesticides. Routine and comprehensive testing of multiresidue pesticides in food is important for regulatory agencies to ensure that concentrations of toxic pesticides are below tolerance levels. Analysis of target pesticides at low concentrations, particularly in grain products and other food products of high fat content, requires cleanup or elimination of matrix interferences prior to chromatographic and mass spectrometric analysis. Although liquid-liquid extraction and gel permeation chromatography (GPC) have been commonly employed for cleanup with multiresidue pesticide analysis (3, 4), solid-phase extraction (SPE) largely replaced these traditional methods due to its selectivity and elimination of large volumes of organic solvents (5-9). The presence of fatty acids produces severe interferences with gas chromatography of pesticides, and their removal is necessary prior to analysis. In recent years, there has been a great amount of interest in using SPE to remove sample matrix components from extracts, with most research focused on reducing or eliminating fatty acids (3-5, 10, 11). Florisil, strong anion-exchange sorbents (SAX) (5, 12), and weak anion-exchange sorbents including primary-secondary amine (PSA) (13, 14), aminopropyl (-NH2) (15, 16), and diethylaminopropyl (DEA) (17) have been investigated for removal of fatty acids naturally occurring in food samples. Of the sorbents involved in previous studies, Florisil was found to be unsuitable for multiresidue pesticide analysis because it strongly adsorbs polar pesticides, such as organophosphate pesticides (