Many clinical laboratories processing large number of samples in a limited time frame require minimal preparative steps to reduce time and cost. In a poster at SOFT 2015 presented by a painmedication monitoring laboratory, the researchers reported a LC-QTOF MS method with minimal sample processing steps. A critical component of this dilute and shoot method was the genetically modified b-glucuronidase, IMCSzyme®, which has higher purity than other commercially available b-glucuronidases,which translates to no interferences identified on the LC-QTOF-MS.