Sorbent Phase Selection Guide

Our reversed phase sorbent is a styrene divinylbenzene polymer with an average particle size of 75 μm. It is ideal for nonpolar and slightly polar compounds.

						
					
Silica

Our silica sorbent is amenable to extraction via hydrogen bonding. It is available in a 40-60 μm particle size range.

						
					
C18

Our C18 sorbent has a silica gel backbone. It is endcapped, with a carbon load of 18-22%, and 40-60 μm particle size range.

						
					
HybridSPE@reg; - Phospholipid Removal

DPX is proud to offer HybridSPE® (a Supelco/Sigma product) sorbent. It is a proprietary zirconia coated silica that selectively removes phospholipids from biological samples.

  • Unique chemistry for excellent recovery of both hydrophobic and hydrophilic analytes
  • Download Application Notes:

  • A Sensitive LC-MS Analysis Method for the Measurement of Nestorone® in Human Serum
  • A Sensitive LC-MS/MS Method for the Measurement of Male Drug Hormones in Human Serum
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    Mixed Mode

    Our mixed mode products are completely customized by choosing any of the above chemistries to combine in one tip. Each sorbent’s mass can also be customized for optimal extraction characteristics for any analyte/matrix combination.

    Ex. WAX/RP, WAX/SCX

    Download Application Notes:

  • Comprehensive Extraction of Drugs/Metabolites in Urine
  • Comprehensive Extraction of Drugs/Metabolites in Oral Fluid
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    DPX + SALLE

    Combine Dispersive Pipette XTRaction and SALLE (Salting-out Assisted Liquid-Liquid Extraction) for a novel cleanup mechanism. XTR tips can house sorbents like WAX or RP for cleanup and the salt (S) necessary for SALLE. This methodology is ideal for applications that require acetonitrile for protein precipitation and are focused on hydrophobic analytes.

    Ex. WAX-S, RP-S

    Aspirate and dispense steps mix sample solution and loose sorbent material. Added salt (S) assists in phase separation during extraction.

    Download Application Notes:

  • THC in Urine
  • THC in Blood
  • Vitamin D from Serum
  • Cortisol in Urine and Saliva
  • Benzos in Meconium