The application of scientific values and practices for legal purposes defines the basics of forensic science. Chemists in the field not only examine a wide variety of samples of forensic interest, but also interpret data acquired from the analytical investigation to present in civil and/or criminal judicial proceedings. Continual advances in the area of forensic analysis are essential because applications of forensic chemistry have broad implications in the establishment of evidential value of the analyzed sample to the court of law with a superior level of quality assurance. An important first step in forensic chemical analysis is sampling and sample preparation, especially when working with trace and ultra-trace levels of the target analyte(s) present in various complex matrices (e.g., soil, biological, environmental, drug, and fire-debris), and the amount of the sample available to the investigator is limited, as in most cases. Considering the complex nature of the sample matrix in which the desired analyte(s) is present, the samples cannot be introduced directly into the analytical instrument for qualitative/quantitative chemical analyses. This is because the complex sample matrix can damage the performance of the analytical instrument if introduced without prior sample treatment/clean-up procedures and the concentration of the analyte of interest in the sample matrix may be lower than minimum limits of detection (LOD) of the instrument. Unlike with other disciplines, it is difficult to standardize the analytical approach to sampling and sample preparation, as every forensic case is unique. Although conventional sample preparation techniques [e.g., liquid-liquid extraction (LLE), solid-phase extraction (SPE),.....